微生物学，博士/博士后，中共党员、副教授、硕士研究生导师，入选湖南省湖湘青年英才，担任湖南省食品科学技术学会理事、湖南省生物化学与分子生物学会青年委员会委员。

电话：0731-85258365

E-mail：haowu@csust.edu.cn

【个人简介】

2019年毕业于广西大学获微生物学博士学位，2019-2021年于江南大学食品科学与资源挖掘全国重点实验室从事博士后研究。2021年12月入职bat365在线唯一官网登录食品与生物工程学院，现为生物工程系副教授、硕士研究生导师。研究方向为代谢工程与合成生物学、蛋白质工程、食品生物技术。先后主持国家自然科学基金、湖湘青年英才（荷尖）人才计划、湖南省自然科学基金、湖南省教育厅、全国重点实验室开放课题等科研项目和研究生教研教改项目。在国内外学术期刊发表科研论文50余篇，教研教改论文2篇，参与编写英文专著2章节，指导学生获全国大学生生命科学竞赛科学探究类第八届（一等奖1项）、第九届（一等奖和三等奖各1项）；生命科学竞赛创新创业类第八届（三等奖1项）、第九届（二等奖1项）；国家级大学生创新创业训练计划项目指导教师；本科生优秀毕业论文指导教师；获湖南省研究生课程思政教学课堂竞赛三等奖、bat365在线唯一官网登录首届研究生课程思政教学课堂竞赛一等奖。兼任Frontiers in Bioengineering and Biotechnology、Metabolites客座编辑，Food and Health、Food Innovation and Advances、Journal of Future Foods、Advanced Biotechnology青年编委；国家自然科学基金函评专家、教育部学位论文评审专家、生命科学竞赛网评专家、湖南科技厅和广西科技厅专家等。

【主讲课程】

研究生：《现代分子生物学（双语）》、《食品生物技术进展》、《酶工程研究进展》、《合成生物学》、《制药工艺与技术》、《高级生物化学》、《生化分离》（留学生）

本科生：《生物化学A》、《生物化学A 实验》

【主要研究领域】

1.新型食品酶资源挖掘与催化机理、酶分子设计与改造

2.生物活性肽功能挖掘及作用机制研究

【主要科研项目】

1.国家自然科学基金青年项目：计算设计提高D-来苏糖异构酶热稳定性的分子改造及其机理研究（32201963），2023-2025年，主持

2.湖南省自然科学基金青年项目：基于酸碱氨基酸置换的D-来苏糖异构酶嗜酸性改造及其分子机制研究（2023JJ40018），2023-2025，主持

3.湖南省创新平台与人才计划：湖湘青年英才科技创新类（2023RC3137），2023-2026，主持

【主要科研论文】

[1] Hao Wu, Qiuming Chen, Wenli Zhang*, Wanmeng Mu. Overview of strategies for developing high thermostability industrial enzymes: Discovery, mechanism, modification and challenges [J]. Critical Reviews in Food Science and Nutrition, 2023, 63(14):2057-2073.

[2] Hao Wu, Ming Yi, Xiaoyi Wu, Yating Ding, Minghui Pu, Li Wen, Yunhui Cheng, Wenli Zhang, Wanmeng Mu. Engineering the thermostability of D-lyxose isomerase from Caldanaerobius polysaccharolyticus via multiple computer-aided rational design for efficient synthesis of D-mannose [J]. Synthetic and Systems Biotechnology, 2023,8:323-330.

[3] Hao Wu, Cuie Guang, Wenli Zhang*, Wanmeng Mu. Recent development of phenyllactic acid: Physicochemical properties, biotechnological production strategies and applications [J]. Critical Reviews in Biotechnology, 2023, 43(2):293-308.

[4] Hao Wu, Wanmeng Mu*. Application prospects and opportunities of inorganic nanomaterials for enzyme immobilization in the food-processing industry [J]. Current Opinion in Food Science, 2022, 47:100909.

[5] Hao Wu, Ming Chen, Cuie Guang, Wenli Zhang*, Wanmeng Mu. Identification of a novel recombinant D-lyxose isomerase from Thermoprotei archaeon with high thermostable, weak-acid and nickel ion dependent properties [J]. International Journal of Biological Macromolecules, 2020,164:1267-1274.

[6] Hao Wu, Wei Zeng, Lei Chen, Bo Yu, Ye Guo, Guiguang Chen, Zhiqun Liang*. Integrated multi-spectroscopic and molecular docking techniques to probe the interaction mechanism between maltase and 1-deoxynojirimycin, an α-glucosidase inhibitor [J]. International Journal of Biological Macromolecules, 2018,114:1194-1202.

[7] Hao Wu, Ye Guo, Lei Chen, Guiguang Chen, Zhiqun Liang*. A novel strategy to regulate 1-deoxynojirimycin production based on its biosynthetic pathway in Streptomyces lavendulae [J]. Frontiers in Microbiology, 2019,10:1968.

[8] Hao Wu, Ming Chen, Cuie Guang*, Wenli Zhang, Wanmeng Mu. Characterization of a recombinant D-mannose-producing D-lyxose isomerase from Caldanaerobius polysaccharolyticus [J]. Enzyme and Microbial Technology, 2020,138:109553.

[9] Hao Wu, Jiawei Huang, Yu Deng*, Wenli Zhang*, Wanmeng Mu. Production of L-ribose from L-arabinose by co-expression of L-arabinose isomerase and D-lyxose isomerase in Escherichia coli [J]. Enzyme and Microbial Technology, 2020,132:109443.

[10] Hao Wu+, Wei Zeng+, Guiguang Chen+, Ye Guo, Chengzhen Yao, Juan Li, Zhiqun Liang*. Spectroscopic techniques investigation on the interaction of glucoamylase with 1-deoxynojirimycin: Mechanistic and conformational study [J]. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 2019,206:613-621.

[11] Hao Wu, Wenli Zhang, Wanmeng Mu*. Recent studies on the biological production of D-mannose [J]. Applied Microbiology and Biotechnology, 2019,103:8753-8761.

[12] Hao Wu+, Xianbo Cheng+, Yongfeng Zhu, Wei Zeng, Guiguang Chen, Zhiqun Liang*. Purification and characterization of a cellulase-free, thermostable endo-xylanase from Streptomyces griseorubens LH-3 and its use in biobleaching on eucalyptus kraft pulp [J]. Journal of Bioscience and Bioengineering, 2018,125(1):46-51.

[13] Hao Wu+, Guiguang Chen+, Yaxi Bian, Wei Zeng, Bihong Sun, Zhiqun Liang*. Identification and characterization of a new agar-degrading strain with the novel properties of saccharides inhibition and nitrogen fixation [J]. Journal of Microbiology, 2017,55(6):475-482.

[14] Hao Wu*, Qiuming Chen. D-Mannose-producing isomerases and epimerases: properties, comparisons, and different strategies. In Book Novel enzymes for functional carbohydrates production, 1st ed; Editor Wanmeng Mu, Wenli Zhang, Qiuming Chen, Eds; Publisher: Springer Nature Singapore, 2021, 43-61.

[15] Hao Wu*, Wei Xu. L-Arabinose isomerase: sources, biochemical properties, and its use to produce D-tagatose. In Book Novel enzymes for functional carbohydrates production, 1st ed; Editor Wanmeng Mu, Wenli Zhang, Qiuming Chen, Eds; Publisher: Springer Nature Singapore, 2021, 63-84.

[16] Hao Wu, Ye Guo, Lei Chen, Guiguang Chen, Zhiqun Liang*. A novel strategy to regulate 1-deoxynojirimycin production based on its biosynthetic pathway in Streptomyces lavendulae [J]. Front Microbiol, 2019,10:1968.

[17] Hao Wu+, Guiguang Chen+, Yaxi Bian, Wei Zeng, Bihong Sun, Zhiqun Liang*. Identification and characterization of a new agar-degrading strain with the novel properties of saccharides inhibition and nitrogen fixation [J]. J Microbiol, 2017,55(6):475-482

[18]吴昊,黄嘉苇,张文立,沐万孟*.重组共表达大肠杆菌细胞从D-葡萄糖一锅法生产D-甘露糖[J].微生物学通报,2020,47(7):2151-2160.

[19] Fan Zhu, Shuwen He, Ce Ni, Ying Wu, Hao Wu*, Li Wen*. Study on the structure–activity relationship of rice immunopeptides based on molecular docking [J]. Food Chemistry X:2024, 21, 101158.

[20] Yun-Hui Cheng, Bu-Qing Liu, Bo Cui, Li Wen, Zhou Xu, Mao-Long Chen, Hao Wu*.Alanine substitution to determine the effect of LR5 and YR6 rice peptide structure on antioxidant and anti-inflammatory activity [J]. Nutrients, 2023, 15(10):2373.

[21] Geng Chen, Hao Wu*, Yingying Zhu, Li Wan, Wenli Zhang, and Wanmeng Mu*. Glycosyltransferase from Bacteroides gallinaceum is a novel α-1,3-fucosyltransferase that can be used for 3-fucosyllactose production in vivo by metabolically engineered Escherichia coli [J]. Journal of Agricultural and Food Chemistry, 2022,70(6):1934-1942.

[22] Duoduo Hu, Hao Wu*, Yingying Zhu, Wenli Zhang, Wanmeng Mu*. Engineering Escherichia coli for highly efficient production of lacto-N-triose II from N-acetylglucosamine, the monomer of chitin [J]. Biotechnology for Biofules, 2021,14:198

[23] Ming Chen, Wenli Zhang, Hao Wu*, Cuie Guang, Wanmeng Mu. Mannitol: physiological functionalities, determination methods, biotechnological production, and applications [J]. Applied Microbiology and Biotechnology, 2020,104:6941-6951.

[24] Ming Chen, Hao Wu*, Wenli Zhang, Wanmeng Mu. Microbial and enzymatic strategies for the production of L-ribose [J]. Applied Microbiology and Biotechnology, 2020,104:3321-3329.

[25] Wenli Zhang, Wanmeng Mu, Hao Wu*, Zhiqun Liang*. An overview of the biological production of 1-deoxynojirimycin: current status and future perspective [J]. Applied Microbiology and Biotechnology, 2019,103:9335-9344.

[26] 吴晓怡, 吴昊*, 杨灿, 文诗雨, 段艳婷, 谭文芝, 谢雨菲, 程云辉, 文李*. 蛋白质工程提升糖酶热稳定性研究进展[J].食品科学,2024,45 (19): 263-271.

[27] 韩鹏薇, 易彤, 李虹辉, 吴昊*, 李彦, 褚武英. 虾壳源蛋白水解物降糖降脂活性评价及肽序分析[J].食品与机械 ,2024,40(4): 148-157.

每一位研究生都有无穷的潜力，欢迎有志于从事食品生物技术研究的同学报考！这里将给予大家最好的平台，共同创造美好未来！